| 產(chǎn)品編號(hào) | IHC0334H |
| 英文名稱 | Human ASK1 Ready-To-Use IHC Kit |
| 中文名稱 | 人細(xì)胞凋亡信號(hào)調(diào)節(jié)激酶1即用型免疫組化試劑盒 |
| 別 名 | MAP3K5; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; Apoptosis signal-regulating kinase 1; ASK-1; ASK1; MAPKKK5; MEKK5; M3K5_HUMAN |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues. SWISS: Q99683 Gene ID: 4217 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human heart tissue slide using IHC0334H (Human ASK1 Kit).
Immunohistochemical analysis of paraffin embedded human testis tissue slide using IHC0334H (Human ASK1 Kit).
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